Summary
- Acronym: PHOTOBIOACETALS
- Title: Photocatalytic production of glycerol acetals used as bio-solvents, pro-perfumes and pro-drugs (PHOTOBIOACETALS).
- Reference: TED2021-132224B-I00
- Duration: From 01/12/2022 to 30/11/2024
- Funding: MCIN/AEI/10.13039/501100011033/ y Unión Europea "NextGenerationEU/PRTR"
Summary
The present proposal is aimed at synthesizing diverse acetals of interest as bio-solvents, pro-perfume and pro-drug. Different second generation biomass-derived chemicals will be used as the raw materials whereas several photocatalysts and solar light as the energy source will be utilized. This will contribute to ecological transition since the biomass-derived raw materials will contribute to zero-emission while not-competing with food and the energy of choice is renewable (solar light). Moreover, the processes will be conducted in flow and using a separation membrane, thus contributing to one of the main challenges of industrial chemical processes in the context of sustainability: process intensification.
The proposal is based on a prior publication of ours (Hidalgo-Carrillo et al, J. Taiwan Inst. Chem. Eng., 125 (2021) 297303) which describes a new photocatalytic route for solketal, a very versatile chemical with multiple uses, one of them as bio-solvent. The synthesis will be optimized to use the visible light of the solar spectrum (resorting to WO3-based photocatalysts) and intensifying the process through flow reaction with a permeable membrane which separates water as it is produced, thus shifting the reaction equilibrium to the desired product. The same approach will be extended to acetalization of cinnamaldehyde with glycerol producing a pro-perfume and acetalization of 3,4-dihydroxybenzaldehyde with glycerol yielding a pro-drug. In both cases, subsequent release of the aldehyde under different conditions (e.g. pH change) will be essayed and the photocatalytic process will be compared to the conventional acid-catalyzed synthesis.
The proposal may impact on chemical production technologies in general and, from a point of view of immediate applicability, the cosmetic and pharmaceutical industry. Furthermore, it can contribute to the development of economically depressed regions, creating new jobs through the valorisation of unexploited biomass resources (i.e. not competing with food) to produce commodity (biosolvents) or fine (pro-drugs, pro-perfume) chemicals. All in all, the planned research perfectly fits into ecological transition, contributing to two of the environmental objectives contained in EU Regulation 2020/852 of the European Parliament and of the Council of June 18th, 2020 (known as the "Taxonomy Regulation"): i) climate change mitigation and ii) transition to a circular economy.
Figure1. Different processes covered in PHOTOBIOACETAL proposal.
Team
Team
- Prof. Francisco J. Urbano (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.), PI. ORCID: 0000-0002-3489-1601
- Prof. Alberto Marinas (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.), co-PI. ORCID: 0000-0002-2693-0711
- Prof. Felipa M. Bautista (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). ORCID: 0000-0002-3558-4072
- Dr Jesús Hidalgo-Carrillo (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). ORCID: 0000-0001-6403-4734
- Dr. Miguel Castillo Rodriguez (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). ORCID: 0000-0002-5592-0010
Collaborators
- Dr Rafael C. Estévez (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). ORCID: 0000-0003-0440-0629
- Dr Juan Martin-Gómez (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). ORCID: 0000-0002-0791-7490
- Dr Francisco Javier López-Tenllado (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.) ORCID: 0000-0002-1807-7829
- Dr. Laura M. Aguado-Deblas (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.) ORCID: 0000-0002-5332-0775
- María C. Herrera-Beurnio (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.) ORCID: 0 000-0002-6707-9804
International Collaborators
- Dr María luisa Testa (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). Istituto per lo Studio dei Materiali (Italy) ORCID: 0000-0003-1898-6608
- Dr Chantal Guillard (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). IRCELYON-UNIVERSITE CLAUDE BERNARD LYON 1 (France) ORCID: 0000-0002-9527-827X
Publications
Publications
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1. Estevez R., López-Tenllado F.J., Aguado-Deblas L., Bautista F.M., Romero A.A., Luna D. Current Research on Green Ammonia (NH3) as a Potential Vector Energy for Power Storage and Engine Fuels: A Review, Energies, (2023) 16 (14), art. no. 5451. DOI: 10.3390/en16145451
