febrero 2020

Protective effect of Pedro-Ximénez must against p,p’-DDE-induced liver damages in aged Mus spretus mice

Noelia Morales-Prieto, Nieves López de Lerma, Isabel L. Pacheco, Paula V. Huertas-Abrila, José Pérez, Rafael Peinado, Nieves Abril

Accede

• p,p'-DDE altered the plasma levels of glucose, triglycerides, and urea and the MDA concentration in mice. • p,p’-DDE perturbs the hepatic redox status, glucose physiology, several central signaling pathways, and hormone metabolism. • The antioxidant properties of Pedro Ximenez must (PXM) polyphenols prevent many of the toxic effects of p,p'-DDE. • PXM dietary intervention will improve the overall health of the elderly and promote healthier aging.

Abstract

Aging is characterized by deterioration of biomolecules and impaired stress responses that make the elderly especially vulnerable to environmental pollutants. The pesticide p,p’-DDE is a DDT derivative that generates great concern because of its wide distribution and its harmful effects on both human health and the environment. We analyzed here the biological responses elicited by p,p’-DDE exposure in the liver of aged Mus spretus mice. Data demonstrate that the elderly constitute a population especially sensitive to this noxious environmental pollutant. We also demonstrated here that the daily consumption of sun-dried Pedro Ximénez (PX) white-grape must (PXM) protects the liver of aged mice from both the age and the damages caused by p,p’-DDE exposure. The PXM activity was exerted through the restoration of the hepatic metabolisms of lipids and carbohydrates and, probably, is a consequence of the ability of this polyphenol-rich mixture to avoid oxidative stress. Nutritional interventions including PXM, which ameliorates the effects of unavoidable exposure to pesticides in our food, are helpful tools that can help elderly populations to enjoy a healthy and expanded lifetime.

Aging Hepatoprotection Mus spretus Oxidative damage p p'-DDEOrganochlorine Pedro-ximénez grape must Transcriptional analysis