Master’s Projects

Obtaining PNKP knock-down cell lines

• Author: Carmen Mª Ayala Roldán
• Supervisor: Mª Isabel Martínez Macías
• Tutor: Mª Teresa Morales Ruiz
• Date: 2023

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Mutational analysis of the AP lyase activity of the FPG enzyme from Arabidopsis thaliana

• Author: Lucía Cabrera González
• Supervisor: Rafael Rodríguez Ariza
• Tutor: Dolores Córdoba Cañero
• Date: 2022

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Study of DNA repair in tumour cells

• Author: Ariadna Muñoz Fernández
• Supervisor: Mª Teresa Roldán Arjona
• Tutor: Mª Isabel Martínez Macías
• Date: 2021

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Analysis of the DNA repair activity of the FPG enzyme from Arabidopsis thaliana

• Author: Rut Fernández Santos
• Supervisor: Rafael Rodríguez Ariza
• Tutor: Dolores Córdoba Cañero
• Date: 2021

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Relevance of an AP lyase / DNA 3'-phosphatase pathway in the repair of abasic sites in human cells.

• Author: Marina Jordano Raya
• Supervisor: Rafael Rodríguez Ariza
• Tutor: Dolores Córdoba Cañero
• Date: 2020

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Targeted reactivation of histone H1F0 in tumor cells.

• Author: Elena Ramos Varas
• Supervisor: Mª Teresa Roldán Arjona
• Tutor: Mª Isabel Martínez Macías
• Date: 2020

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Analysis of the substrate specificity of two DNA repair enzymes, ARP and FPG, in Arabidopsis thaliana cell extracts.

• Author: María Dolores Moreno Recio
• Supervisor: Rafael Rodríguez Ariza
• Tutor: Dolores Córdoba Cañero
• Date: 2019

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Transient DNA demethylation: effect on gene expression.

• Author: Manuel Remesal González
• Supervisor: Mª Teresa Roldán Arjona
• Tutor: Mª Victoria García Ortiz
• Date: 2019

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Analysis of methylation and gene expression in murine xenograft expressing a plant demethylase after treatment with 5-Fluorouracil.

• Author: Rocío Regalado Cordero
• Supervisor: Mª Teresa Roldán Arjona
• Tutor: Mª Teresa Morales Ruiz
• Date: 2019

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Analysis of the substrate specificity of the AP endonuclease ARP and the AP lyase FPG from Arabidopsis thaliana.

• Author: Cristina Beltrán Melero
• Supervisor: Rafael Rodríguez Ariza
• Tutor: Dolores Córdoba Cañero
• Date: 2018

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Effect of a plant demethylase expression in murine colon cancer xenografts.

• Author: José Antonio Crespo Matas
• Supervisor: Mª Teresa Roldán Arjona
• Tutor: Mª Teresa Morales Ruiz
• Date: 2018

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Role of poly ADP-ribosylation in DNA base excision repair in plants

• Author: Ester García Perejón
• Supervisor: Rafael Rodríguez Ariza
• Tutor: Dolores Córdoba Cañero
• Date: 2017

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Study of methylation and expression patterns in DNA methyltransferases from tumor cells

• Author: Paul Fernando Balderrama Aguilar
• Supervisor: Mª Teresa Morales Ruiz
• Tutor: Mª Victoria García Ortiz
• Date: 2017

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Development of a detection system to analyze gene silencing mechanisms

• Author: Macarena Dorado León
• Supervisor: Mª Teresa Morales Ruiz
• Tutor: Mª Victoria García Ortiz
• Date: 2016

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Alteration of cell cycle in tumor cells through DNA desmetylase expression from Arabidopsis thaliana

• Author: Laura Raya Ruiz
• Supervisor: Mª Teresa Morales Ruiz
• Tutor: Mª Victoria García Ortiz
• Date: 2015

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Detection of epigenetic alterations using minimally invasive methods as diagnostic tool for human carcinogenesis

• Author: Samah Sfaxi
• Supervisor: Mª Victoria García Ortiz 
• Tutor: Mª Teresa Morales Ruiz
• Date: 2014​

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Functional analysis of 5-methylcitosine DNA glycosylase ROS1 structural domains of Arabidopsis thaliana

• Author: José Antonio Villaécija Aguilar
• Supervisor: Dolores Córdoba Cañero
• Tutor: Rafael Rodríguez Ariza
• Date: 2014

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Epigenome analysis in human tumor lines expressing plant demethylases

• Author: Iván Devesa Guerra
• Supervisor: Teresa Morales Ruiz
• Tutor: Mª Victoria García Ortiz
• Date: 2014

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Implication of the DNA 3'Phosphatase ZDP in N7-methylguanine repair in Arabidopsis thaliana

• Author: Casimiro Barbado García-Gil
• Supervisor: Dolores Córdoba Cañero
• Tutor: Teresa Morales Ruiz
• Date: 2013

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Identification of essential residues for deoxyribose phosphate lyase activity of the DNA λ polymerase of Arabidopsis thaliana

• Author: David Alejandro Ortega Paredes
• Supervisor: Mª Teresa Morales Ruíz
• Tutor: Dolores Córdoba Cañero
• Date: 2012

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Mutational analysis of ROS1 5-methylcytosine DNA glycosylase from Arabidopsis thaliana

• Author: Jara Teresa Parrilla Doblas
• Supervisor: Mª Teresa Roldán Arjona
• Tutor: Mª Isabel Ponferrada Marín
• Date: 2011

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Purification and biochemical characterization of DNA polymerase λ from Arabidopsis thaliana

• Author: Jose Antonio Luna Morilla
• Supervisor: Mª Teresa Morales Ruíz
• Tutor: Dolores Córdoba Cañero
• Date: 2011

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Molecular dissection of the base excision repair pathway in cell extracts from Chlamydomonas reinhardtii 6145c

• Author: Álvaro Carlos Romero Valenzuela
• Supervisor: Dolores Córdoba Cañero
• Tutor: Mª Teresa Morales Ruíz
• Date: 2010

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Protein reversible phosphorylation modulates DNA base excision repair in cell extracts from Arabidopsis thaliana

• Author: Gustavo Adolfo Bravo Ruíz
• Supervisor: Dolores Córdoba Cañero
• Tutor: Mª Teresa Roldán Arjona
• Date: 2009

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Molecular analysis of the base excision repair pathway in the unicellular alga Chlamydomonas reinhardtii

• Author: Vanessa Mª Vázquez Grande
• Supervisor: Mª Teresa Morales Ruíz
• Tutor: Rafael Rodríguez Ariza
• Date: 2009

  Mutational analysis of the AP lyase activity of the FPG enzyme from Arabidopsis thaliana

• Author: Lucía Cabrera González
• Supervisor: Rafael Rodríguez Ariza
• Tutor: Dolores Córdoba Cañero
• Date: 2022

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